ChemicalBook >> CAS DataBase List >>2-Chloronicotinic acid
2-Chloronicotinic acid
- CAS No.
- 2942-59-8
- Chemical Name:
- 2-Chloronicotinic acid
- Synonyms
- 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;AKOS BBS-00004231;2 - chloro niacin;oronicotinic acid;RARECHEM AL BO 0287;TIMTEC-BB SBB004002
- CBNumber:
- CB7714896
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MDL Number:
- MFCD00006236
- MOL File:
- 2942-59-8.mol
- MSDS File:
- SDS
Last updated:2023-06-09 13:57:52
| Melting point | 176-178 °C (dec.)(lit.) |
|---|---|
| Boiling point | 316.8±22.0 °C(Predicted) |
| Density | 1.470±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO, Ethyl Acetate (Slightly) |
| pka | 2.07±0.25(Predicted) |
| form | Powder |
| color | White to cream |
| BRN | 119023 |
| InChIKey | IBRSSZOHCGUTHI-UHFFFAOYSA-N |
| LogP | 0.988 |
| CAS DataBase Reference | 2942-59-8(CAS DataBase Reference) |
| FDA UNII | 93G386213F |
| EPA Substance Registry System | 2-Chloronicotinic acid (2942-59-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | T | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
2-Chloronicotinic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 10g | $47.6 | 2023-06-20 | Buy |
| Sigma-Aldrich | PHR2305 | Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 2942-59-8 | 50MG | $466 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1274629 | Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard | 2942-59-8 | 15mg | $1370 | 2022-05-15 | Buy |
| TCI Chemical | C1108 | 2-Chloronicotinic Acid >98.0%(HPLC)(T) | 2942-59-8 | 25g | $21 | 2023-06-20 | Buy |
| TCI Chemical | C1108 | 2-Chloronicotinic Acid >98.0%(HPLC)(T) | 2942-59-8 | 250g | $99 | 2023-06-20 | Buy |
2-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Application
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.
Preparation
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
Definition
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.
2-Chloronicotinic acid Preparation Products And Raw materials
Global( 872)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
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View Lastest Price from 2-Chloronicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-07 | 2-Chloronicotinic acid
2942-59-8
|
US $0.00 / KG | 1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | |
 |
2023-07-21 | 2-Chloronicotinic acid
2942-59-8
|
US $1.00 / mg | 100mg | 98.0% | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD | |
 |
2023-06-10 | 2-Chloronicotinic acid
2942-59-8
|
US $0.00 / kg | 1kg | 99.0% min | 10tons/month | Hangzhou ICH Biofarm Co., Ltd |
-
- 2-Chloronicotinic acid
2942-59-8
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 2-Chloronicotinic acid
2942-59-8
- US $1.00 / mg
- 98.0%
- ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
-
- 2-Chloronicotinic acid
2942-59-8
- US $0.00 / kg
- 99.0% min
- Hangzhou ICH Biofarm Co., Ltd
2942-59-8(2-Chloronicotinic acid)Related Search:
TIMTEC-BB SBB004002
2-chloro-3-pyridinecarboxylicaci
2-CHLORO-3-PYRIDINECARBOXYLIC ACID
2-CHLOROPYRIDINE-3-CARBOXYLIC ACID
2-CHLOROPYRIDIN-3-CARBOXYLIC ACID
2CLNA
2-CHLORONICOTINIC ACID
RARECHEM AL BO 0287
AKOS BBS-00004231
CHLORONICOTINIC ACID
2-Chloronicotinic Aicd
2-Chloropyridine-3-carboxylic acid, 3-Carboxy-2-chloropyridine
2-chlorine nicotinic acid
2 - chloro niacin
2-Chloronicoti
2-Chloronicotinic acid
2-Chloro-3-pyridinecarboxylic acid
2-Chloropyridine-3-carboxylic acid 99%
Flunixin Related CoMpound A
2-CHLORO-3-CARBOXYLPYRIDINE
2-Chloropyridine-3-carboxylic
2-Chloronicotinic acid 98%
2-Chloro Nicotinc Acid
3-Pyridinecarboxylic acid, 2-chloro-
2-ChloroNicotinicAcid,99%-100.5%
2-CHLORO-3-PYRIDINECARBOXYLIC ACID / 2-CHLORONICOTINIC ACID
2-CHLORONICOTINIC ACID 2-CHLOROPYRIDIN-3-CARBOXYLIC ACID
2-CHLORONITINICACID
2-Chloropyridine-3-carboxylic acid,2-Chloronicotinic acid
2-Chloronicotinic ac
2-chloro-3-picolinate
Flunixin Meglumine Impurity 1（Flunixin Meglumine EP Impurity A）
oronicotinic acid
Flunixin Meglumine EP Impurity A
2-Chloronicotinic Acid >
Niflumic acid impurity A CRS
2-Chlornicotinsaeure
Flunixin EP Impurity A
Niflumic Acid EP Impurity A
2 - nicotinic acid chloride
Flunixin impurity AQ: What is
Flunixin impurity A Q: What is the CAS Number of
Flunixin impurity A Q: What is the storage condition of
Flunixin impurity A Q: What are the applications of
Flunixin impurity A
Flunixin Related Compound A (2-Chloronicotinic acid) (1274629)
Flunixin USP Related Compound A
2-Chloronicotinic acidedione
2-Chloro Nicotinc Aci
Flunixin Meglumine Impurity A
Flunixin Meglumine Impurity 3
2942-59-8
2492-59-8
Pyridines
Halogenated Heterocycles
Heterocyclic Building Blocks
Halopyridines
Chloropyridines
Building Blocks
ACID
pyridine series
blocks
Carboxes