피롤리딘
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피롤리딘 속성
- 녹는점
- -63 °C
- 끓는 점
- 87-88 °C/760 mmHg (lit.)
- 밀도
- 0.852 g/mL at 25 °C (lit.)
- 증기 밀도
- 2.45 (vs air)
- 증기압
- 128 mm Hg ( 39 °C)
- 굴절률
- n
20/D 1.443(lit.)
- FEMA
- 3523 | PYRROLIDINE
- 인화점
- 37 °F
- 저장 조건
- Store below +30°C.
- 용해도
- water: miscible
- 물리적 상태
- Liquid
- 산도 계수 (pKa)
- 11.27(at 25℃)
- 색상
- Colorless to Almost colorless
- 냄새
- at 0.10 % in propylene glycol. ammoniacal animal egg amine
- 수소이온지수(pH)
- 12.9 (100g/l, H2O, 20℃)
- 폭발한계
- 1.6-10.6%(V)
- ?? ??
- ammoniacal
- 수용성
- Miscible with alcohol, ether, chloroform and water.
- 감도
- Air Sensitive
- Merck
- 14,8015
- JECFA Number
- 1609
- BRN
- 102395
- 안정성
- Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
- InChIKey
- RWRDLPDLKQPQOW-UHFFFAOYSA-N
- LogP
- 0.22 at 25℃
- CAS 데이터베이스
- 123-75-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,T,C | ||
---|---|---|---|
위험 카페고리 넘버 | 11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11 | ||
안전지침서 | 16-26-36/37/39-45-33-S45-S36/37/39-S26-S16 | ||
유엔번호(UN No.) | UN 1922 3/PG 2 | ||
WGK 독일 | 2 | ||
RTECS 번호 | UX9650000 | ||
F 고인화성물질 | 34 | ||
자연 발화 온도 | 653 °F | ||
TSCA | Yes | ||
HS 번호 | 2933 99 80 | ||
위험 등급 | 3 | ||
포장분류 | II | ||
유해 물질 데이터 | 123-75-1(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 433 mg/kg | ||
유해화학물질 필터링 | 2019-1-898(신규화학물질) | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 피롤리딘 및 이를 5% 이상 함유한 혼합물 |
피롤리딘 C화학적 특성, 용도, 생산
화학적 성질
Pyrrolidine appears as a colorless to pale yellow liquid with an ammonia-like odor. It is infinitely miscible with water and conventional organic solvents such as methanol, acetone, ether, and chloroform. It acts as a lachrymator.Chemically, pyrrolidine behaves like a secondary amine in every respect. For example, it undergoes Leuckart –Wallach and Mannich reactions and is readily converted into an enamine. In the presence of a catalyst, such as platinum at 360°C or rhodium at 650°C, pyrrole is formed. In the presence of a copper catalyst, N-methylpyrrolidone is converted into N-methylpyrrolidine.
물리적 성질
Pyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is easy to turn yellow when exposed to light or humid air, easily soluble in water and ethanol. It is nauseating and diffusive.출처
Reported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.용도
Pyrrolidine is a flammable alkaline liquid that undergoes reactions typical of secondary amines. It is used to prepare pesticides and rubber accelerators and as a chemical intermediate (usually the hydrochloride form) in the pharmaceutical industry. There is relatively limited industrial exposure to this material.제조 방법
Pyrrolidine is formed by reduction of pyrrole. Via overall 5-endo-trig cyclizations of homoallylic tosylamides. Pyrrolidine can be produced from butanediol and ammonia, e.g., over an aluminum thorium oxide catalyst at 300°C or over a nickel catalyst at 200°C and 20 MPa under hydrogenation conditions. It can also be produced from THF and ammonia over aluminum oxide at 275-375°C.주요 응용
Pyrrolidine is a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs). It has been used for the synthesis of N-benzoyl pyrrolidine from benzaldehyde via oxidative amination. It may be used as a catalyst for the synthesis of N-sulfinyl aldimines from carbonyl compounds and sulfonamides.Pyrrolidine can also be used to synthesize:
Taddol-pyrrolidine phosphoramidite, a ligand for rhodium-catalyzed [2+2+2] cycloaddition of pentenyl isocyanate and 4- ethynylanisole.
H,4 PyrrolidineQuin-BAM (′PBAM′), a selective catalyst for the aza-Henry addition of nitroalkanes to aryl aldimines.
1,2,3,3a,4,9-Hexahydropyrrolo[2,1-b]quinazoline by reacting with o-aminobenzaldehyde.
정의
ChEBI: Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.일반 설명
Pyrrolidine is a saturated heterocycliccompound having one nitrogenatom in a five-membered ring. It is a colorless to pale yellow liquid with an ammonia-like odor. It is found in certain plants andthe ring structure is present in manyalkaloids. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.공기와 물의 반응
Highly flammable. Very soluble in water.반응 프로필
Tetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.위험도
Flammable, dangerous fire risk. Toxic by ingestion and inhalation.건강위험
The acute toxicity of pyrrolidine is moderateon test animals. It is somewhat less toxicthan pyrrole. The vapors are an irritant tothe eyes and respiratory tract. The liquid iscorrosive to the skin. Contact with the eyescan cause damage. The oral LD50 value inrats is 300 mg/kg, while the inhalation LC50value in mice is 1300 mg/m3/2 h (NIOSH1986).화재위험
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.Safety Profile
Poison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.Purification Methods
Dry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]피롤리딘 준비 용품 및 원자재
원자재
준비 용품
Ramipril
METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE
ETHYL 3,5-DIMETHYLISOXAZOLE-4-CARBOXYLATE
Barnidipine
4,5,6,7-TETRAHYDRO-2-METHYLFURO[3,2-C]PYRIDINE
6-Bromoindole-3-carboxaldehyde
Alizapride
6-Benzyloxyindole
Rocuronium bromide
6-(1-PYRROLIDINYL)-3-PYRIDINAMINE
6-Methoxyindole
Gestrinone
6-플루오로트립타민 염산염
N-[2-(4-Bromophenoxy)ethyl]pyrrolidine
Bis(pinacolato)diboron
[6-(1-PYRROLIDINYL)-3-PYRIDINYL]METHANOL
6-Methoxy-1H-indole-3-carbaldehyde
TOSUFLOXACIN TOSILATE
BEPRIDIL
3-Methyl-4-isoxazolecarboxylic acid
3,5-DIMETHYLISOXAZOLE-4-CARBONYL CHLORIDE
4-PYRROLIDINOBUTYLAMINE
5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE
5-BROMO-2-(PYRROLIDIN-1-YL)PYRIDINE
6-(1-PYRROLIDINYL)NICOTINALDEHYDE
Methyl 1-Methyl-2-oxopyrrolidine-3-carboxylate
2-아미노에틸-1-피롤리딘
4-(1-Pyrrolidinyl)piperidine
(2-PYRROLIDIN-1-YL-ETHYL)-HYDRAZINE
1-BENZYL-3-METHYL-4-PIPERIDONE
5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE
Sultopride hydrochloride
PYRROLIDIN-1-YL-ACETIC ACID
1-(4-AMINO-2,6-DICHLOROPHENOXY)-3-(PYRROLIDIN-1-YL)PROPAN-2-OL
3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID
PYRROLIDINE-1-SULFONYL CHLORIDE
1-(2-Chloroethyl)pyrrolidine Hydrochloride
1-(3-PYRROLIDINOPROPYL)PIPERAZINE
Indole-6-carboxylic acid
심바스타틴
피롤리딘 공급 업체
글로벌( 590)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Crovell Biotech Co Ltd | +86-19930503285 |
zoey@crovellbio.com | China | 5740 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8877 | 58 |
Wuhan wingroup Pharmaceutical Co., Ltd | +86-13296627870; +8613296627870 |
info@whwingroup.com | China | 817 | 58 |
Shanxi Lianxu New Material Co., LTD | +86-18903404542 |
vevi@lianxuchemical.com | China | 612 | 58 |
Hangzhou Benoy Chemical Co., Ltd | +8617342059697 |
sales@benoychem.com | China | 315 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 21846 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930507417 +86-19930507417 |
violeta@crovellbio.com | China | 14741 | 58 |
Zibo Dorne Chemical Technology co. LTD | +8618560316533 |
Ethan@dornechem.com | China | 256 | 58 |
Changzhou Zechong Biopharma Co., Ltd. | +undefined18621330623 |
sales@zechongchem.com | China | 28 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29811 | 60 |
피롤리딘 관련 검색:
하이드록시피클리딘 하이드록시에틸-1-메틸피롤리딘 N-니트로소피롤리딘 1-아미노 피롤리딘 에틸(1-)-3-피롤요돈올 피롤리딘 1-메틸피롤리딘 피롤
Tellurium tetrachloride
Tetrahydropyran
Tetrahydro-4H-pyran-4-one
Tetrahydrofuran
1-(3,4-DIHYDRO-2-NAPHTHYL)PYRROLIDINE
3-Carboxy-2,2,5,5-tetraMethylpyrrolidine 1-Oxyl Free Radical
1-Pyrrolidino-1-cyclohexene
1-FORMYLPYRROLIDINE
1-Cyanopyrrolidine
3-CARBAMOYL-PROXYL