L-(-)-루신
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L-(-)-루신 속성
- 녹는점
- >300 °C (lit.)
- 알파
- 15.4 º (c=4, 6N HCl)
- 끓는 점
- 122-134 °C(Press: 2-3 Torr)
- 밀도
- 1,293 g/cm3
- 증기압
- <1 hPa (20 °C)
- 굴절률
- 1.4630 (estimate)
- FEMA
- 3297 | L-LEUCINE
- 인화점
- 145-148°C
- 저장 조건
- 2-8°C
- 용해도
- 1 M HCl: 50 mg/mL
- 물리적 상태
- powder
- 산도 계수 (pKa)
- 2.328(at 25℃)
- 색상
- White to Off-white
- 냄새
- at 100.00?%. odorless
- 수소이온지수(pH)
- 5.5-6.5 (20g/l, H2O, 20℃)
- optical activity
- [α]20/D +15.5°, c = 2 in 6 M HCl
- 수용성
- 22.4 g/L (20 C)
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
- JECFA Number
- 1423
- 승화점
- 145-148 ºC
- Merck
- 14,5451
- BRN
- 1721722
- 안정성
- Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
- LogP
- 0.80
- CAS 데이터베이스
- 61-90-5(CAS DataBase Reference)
- NIST
- Leucine(61-90-5)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 | ||
| RTECS 번호 | OH2850000 | ||
| TSCA | Yes | ||
| HS 번호 | 29224995 | ||
| 유해 물질 데이터 | 61-90-5(Hazardous Substances Data) |
L-(-)-루신 C화학적 특성, 용도, 생산
개요
Small, white, lustrous plates, or a white, crystalline powder, with a slightly bitter taste. One g dissolves in about 40 mL of water and in about 100 mL of acetic acid. It is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. ι-Leucine may be synthesized by bromination, followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.화학적 성질
L-Leucine is odorless and has a slightly bitter taste. L-Leucine is a branched-chain, essential amino acid that stimulates muscle protein synthesis.출처
Reported found as a constituent in proteins; also present in the free state in the human body용도
L-Leucine plays a vital role in hemoglobin formation, protein synthesis and metabolic functions. It assists the growth and repair of muscle and bone tissue. It is used in the treatment of amyotrophic lateral sclerosis - Lou Gehrig's disease. It prevents the breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. It is also used as a food additive and flavor enhancer. Further, it is used to preserve muscle glycogen.제조 방법
By bromination followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.생산 방법
Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.정의
ChEBI: The L-enantiomer of leucine.Pharmaceutical Applications
Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.Safety
Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.LD50 (rat, IP): 5.379 g/kg
저장
Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.Purification Methods
Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]비 호환성
Leucine is incompatible with strong oxidizing agents.Regulatory Status
Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.L-(-)-루신 준비 용품 및 원자재
원자재
Concentrated hydrochloric acid
케라틴
펜프로바메이트
o-자일렌
dilute sulphuric acid
L-(+)-아이소루신
헤모글로빈
Α-PROTEIN
granular active carbon
염산
Naphthalene-2-sulfonic acid
카세인
o-브로모톨루엔
Sodium sulfonate
L-메티오닌
암모늄 비카보네이트
활성화 챠콜
N-CARBOBENZOXY-DL-LEUCINE
황산
암모니아(가스)
준비 용품
L-(-)-루신 공급 업체
글로벌( 862)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Qingdao Trust Agri Chemical Co.,Ltd | +86-008613573296305 |
aroma@qdtrustagri.com | China | 160 | 58 |
| HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD | +86-19933070948 +86-19930599843 |
claire@hbyingong.com | China | 945 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 |
donboo@donboo.com | China | 9346 | 58 |
| Maanshan Tiantai Biotechnology Co., Ltd. | +86-0555-8889890 +86-18656552636 |
shenguangguang@tiantaibio-tech.com | China | 72 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 972 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29811 | 60 |
| Henan DaKen Chemical CO.,LTD. | +86-371-66670886 |
info@dakenchem.com | China | 18729 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 |
bj1@bj-chem.com | China | 296 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |