부틸산화 히드록시톨루엔
|
|
부틸산화 히드록시톨루엔 속성
- 녹는점
- 69-73 °C(lit.)
- 끓는 점
- 265 °C(lit.)
- 밀도
- 1.048
- 증기 밀도
- 7.6 (vs air)
- 증기압
- <0.01 mm Hg ( 20 °C)
- 굴절률
- 1.4859
- 인화점
- 127 °C
- 저장 조건
- 2-8°C
- 용해도
- methanol: 0.1 g/mL, clear, colorless
- 물리적 상태
- Crystals
- 산도 계수 (pKa)
- pKa 14(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
- 색상
- white
- 냄새
- faint characteristic odor
- ?? ??
- phenolic
- 수용성
- insoluble
- Merck
- 14,1548
- BRN
- 1911640
- 노출 한도
- ACGIH: TWA 2 mg/m3
NIOSH: TWA 10 mg/m3
- 안정성
- Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
- InChIKey
- NLZUEZXRPGMBCV-UHFFFAOYSA-N
- LogP
- 5.2
- CAS 데이터베이스
- 128-37-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 40, Sup 7) 1987
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-36/38-50/53 | ||
안전지침서 | 26-36-37/39-61-60 | ||
유엔번호(UN No.) | 3077 | ||
WGK 독일 | 1 | ||
RTECS 번호 | GO7875000 | ||
F 고인화성물질 | 8-10-23 | ||
자연 발화 온도 | 878 °F | ||
TSCA | Yes | ||
위험 등급 | 9 | ||
포장분류 | III | ||
HS 번호 | 29071900 | ||
유해 물질 데이터 | 128-37-0(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: 1040 mg/kg (McOmie) | ||
기존화학 물질 | KE-03079 |
부틸산화 히드록시톨루엔 C화학적 특성, 용도, 생산
개요
The antioxidant butylated hydroxytoluene is contained in food, adhesive glues, industrial oils and greases, including cutting fluids. Sensitization seems very rare.화학적 성질
Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.출처
Not reported found naturally.용도
Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.정의
ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.생산 방법
Prepared by the reaction of p-cresol with isobutene.제조 방법
Butylated Hydroxytoluene is produced commercially by the alkylation of para-cresol with isobutylene. Butylated Hydroxytoluene is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.일반 설명
White crystalline solid.공기와 물의 반응
Insoluble in water.반응 프로필
Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.건강위험
2,6-Di-tert-butyl-p-cresol or Butylated Hydroxytoluene is of relatively low acute toxicity in animals, and there is no evidence of either acute or chronic effects among exposed workers.화재위험
2,6-Di-tert-butyl-4-methylphenol is combustible.Pharmaceutical Applications
Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.
색상 색인 번호
This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.Carcinogenicity
The IARC has determined that there is limited evidence for the carcinogenicity of Butylated Hydroxytoluene in experimental animals.Butylated Hydroxytoluene has given primarily negative results in a large number of in vivo and in vitro genotoxic assays.No significant reproductive effects were observed in three-generation toxicity studies in mice administered up to 0.4% in the diet.6 The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2,6-ditert- butyl-p-cresol is 2mg/m3.환경귀착
The metabolites of Butylated Hydroxytoluene can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.잠재적 노출
DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.Safety Profile
Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand.Safety
Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
LD50 (guinea pig, oral): 10.7 g/kg
LD50 (mouse, IP): 0.14 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 0.65 g/kg
LD50 (rat, oral): 0.89 g/kg
저장
Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Purification Methods
Dissolve Butylated Hydroxytoluene in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]비 호환성
Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.부틸산화 히드록시톨루엔 준비 용품 및 원자재
원자재
준비 용품
부틸산화 히드록시톨루엔 공급 업체
글로벌( 1178)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Tianjin Zhongxin Chemtech Co., Ltd. | +86-022-66880623 +8618622897568 |
sales@tjzxchem.com | China | 548 | 58 |
Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 |
info@nxjhchem.com | China | 70 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2180 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29811 | 60 |
Henan DaKen Chemical CO.,LTD. | +86-371-66670886 |
info@dakenchem.com | China | 18729 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
fandachem@gmail.com | China | 9378 | 55 |
Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 |
marketing@royal-chem.com | China | 535 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2990 | 55 |
Chemson Industrial (Shanghai) Co., Ltd. | 86-21-65208861- 8007 |
sales1@chemson.com.cn | CHINA | 117 | 58 |