인돌
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인돌 속성
- 녹는점
- 51-54 °C (lit.)
- 끓는 점
- 253-254 °C (lit.)
- 밀도
- 1.22
- 증기압
- 0.016 hPa (25 °C)
- FEMA
- 2593 | INDOLE
- 굴절률
- 1.6300
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- methanol: 0.1 g/mL, clear
- 물리적 상태
- Crystalline Powder
- 산도 계수 (pKa)
- 3.17 (quoted, Sangster, 1989)
- 색상
- White to slightly pink
- 수소이온지수(pH)
- 5.9 (1000g/l, H2O, 20℃)
- 냄새
- fecal odor, floral in high dilution
- ?? ??
- animal
- Odor Threshold
- 0.0003ppm
- 수용성
- 2.80 g/L (25 ºC)
- 감도
- Light Sensitive
- Merck
- 14,4963
- JECFA Number
- 1301
- BRN
- 107693
- 안정성
- Stable, but may be light or air sensitive. Incompatible with strong oxidizing agents, iron and iron salts.
- LogP
- 2.14-2.24
- CAS 데이터베이스
- 120-72-9(CAS DataBase Reference)
- NIST
- Indole(120-72-9)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,N,T | ||
---|---|---|---|
위험 카페고리 넘버 | 21/22-37/38-41-50/53-36-39/23/24/25-23/24/25-52/53 | ||
안전지침서 | 26-36/37/39-60-61-45-36/37 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 1 | ||
RTECS 번호 | NL2450000 | ||
F 고인화성물질 | 8-13 | ||
TSCA | Yes | ||
HS 번호 | 2933 99 20 | ||
위험 등급 | 9 | ||
포장분류 | III | ||
유해 물질 데이터 | 120-72-9(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 1 g/kg (Smyth) | ||
기존화학 물질 | KE-21007 |
인돌 C화학적 특성, 용도, 생산
개요
Indole has an almost floral odor when highly purified. Otherwise, it exhibits the characteristic odor of feces. It is not very stable on exposure to light (turns red). Indole may be obtained from the 220 - 260°C boiling fraction of coal tar or by heating sodium phenylglycine-o-carboxylate with NaOH, saturating the aqueous solution of the melt with C 02, and finally reducing with sodium amalgam; can be prepared also by the reduction of indoxyl, indoxyl carboxylic acid, or indigo.화학적 성질
Indole has an unpleasant odor at high concentration, odor becomes floral at higher dilutions물리적 성질
Colorless to yellow scales with an unpleasant odor. Turns red on exposure to light and air. Odor threshold of 0.14 ppm was reported by Buttery et al. (1988).출처
Reported occurring in several natural products as a complex compound that decomposes during enfleurage or steam distillation yielding free indole; reported found in the essential oil from flower of Jasminum grandiflorum, in neroli oil and in the oil extracted from flowers of bitter orange; also reported in the flowers of several plants: lemon, coffee, Hevea brasiliensis and Randia formosa in the oil extracted from flowers of Jasminum odoratissinium L. and in the oil of Narcissus jonquilla. Also reported found in apricot, mandarin orange peel oil, grapes, kohlrabi, French fried potato, crispbread, cheeses, butter, milk, milk powder, boiled egg, fish oil, chicken, beef, pork, beer, rum, Finnish whiskey, red and white wine, coffee, tea, soybean, mushrooms, cauliflower, figs, rice, licorice, buckwheat, malt, wort, elder flower, clary sage, shrimp, okra, crab, clam, squid and green maté용도
In highly dil solutions the odor is pleasant, hence indole has been used in perfumery.제조 방법
Obtained from the 220 to 260°C boiling fraction of coal tar or by heating sodium phenyl-glycine-o-carboxylate with NaOH, saturating the aqueous solution of the melt with CO2 and finally reducing with sodium amalgam; can be prepared also by the reduction of indoxyl, indoxyl carboxylic acid or indigo.정의
indole: A yellow solid, C8H7N, m.p.52°C. Its molecules consist of a benzenering fused to a nitrogen-containingfive-membered ring. It occurs insome plants and in coal tar, and isproduced in faeces by bacterial action.It is used in making perfumes.Indole has the nitrogen atom positionednext to the fused benzenering. An isomer with the nitrogentwo atoms away from the fused ringis called isoindole.일반 설명
Indole is classified under the volatile flavor compounds (VFCs). It is known to play significant role in various biological functions such as anti-inflammatory, anticonvulsant, cardiovascular and antibacterial activities.위험도
A carcinogen.건강위험
Low to moderate toxicity was observed inexperimental animals resulting from oral orsubcutaneous administration of indole. Theoral LD50 value in rats is 1000 mg/kg. It is ananimal carcinogen. It caused tumors in bloodand lungs in mice subjected to subcutaneousadministration.화재위험
Noncombustible solid.환경귀착
Biological. In 9% anaerobic municipal sludge, indole degraded to 1,3-dihydro-2H-indol-2-one (oxindole), which degraded to methane and carbon dioxide (Berry et al., 1987). Heukelekian and Rand (1955) reported a 5-d BOD value of 1.70 g/g which is 65.4% of the ThOD value of 2.48 g/g.Chemical/Physical. The aqueous chlorination of indole by hypochlorite/hypochlorous acid, chlorine dioxide, and chloramines produced oxindole, isatin, and possibly 3-chloroindole (Lin and Carlson, 1984).
신진 대사 경로
The indole is metabolized in a mineral salt medium inoculated with 9% anaerobically digested nitrate- reducing sewage sludge, resulting in the sequential occurrence of four structurally related compounds: oxindole, isatine, dioxindole, and anthranilic acid. Indole is metabolized by fungus via indoxyl (3-hydroxyindole), N-formylanthranilic acid, anthranilic acid, 2,3-dihydroxybenzoic acid, and catecol, which is further degraded by an ortho cleavage.신진 대사
Indole is oxidized to 3-hydroxyindole (indoxyl) which is conjugated with glucuronic and sulphuric acids before excretion. The sulphate conjugate seems to be the main product in rabbits and, even with relatively large doses of indole, the sulphate conjugation always exceeds that of glucuronic acid(Williams, 1959).Purification Methods
It can be further purified by sublimation in a vacuum or by zone melting. The picrate forms orange crystals from EtOH and has m 175o. [Beilstein 20 II 196, 20 III/IV 3176, 20/7 V 5.]인돌 준비 용품 및 원자재
원자재
Methylnaphthalene fraction
아연
질산 알루미늄
니트로톨루엔
Iron filings
2- oxindole
2-Nitrophenylpyruvic acid
이사틴
Phenyl glycine
에틸아닐린(2-)
1H-INDOL-3-OL
삼산화크롬무수물
인돌린
콜타르 증류액
염화알루미늄
Polishing oil
인디고
준비 용품
Ziprasidone hydrochloride monohydrate
1-Methyl-1H-indole-3-carboxylic acid
3-BROMO-1-(TRIISOPROPYLSILYL)INDOLE
5-Nitroindole
Etodolac
1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOLE-3-CARBALDEHYDE
3-인돌부틸산
트리메틸-1,3,3,-2-메틸렌인돌린
L-트립토판
4-히드록시인돌
5-Cyanoindole
DL-트립토판
Ziprasidone
그라민
5-Fluoroindole
인디고
인돌-3-아세트산
Ropinirole
1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBALDEHYDE
3-((Piperidin-1-yl)methyl)-1H-indole ,98%
인돌 공급 업체
글로벌( 658)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shandong Natural Micron Pharm Tech Co.,LTD | +86-18653895227 |
info@nmpharmtech.com | China | 94 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 |
dominicguo@gk-bio.com | CHINA | 9427 | 58 |
Hebei Mojin Biotechnology Co., Ltd | 15028179902 +8615028179902 |
sales@hbmojin.com | China | 7044 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29811 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
fandachem@gmail.com | China | 9378 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 31969 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29922 | 58 |