피페라진
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피페라진 속성
- 녹는점
- 109-112 °C (lit.)
- 끓는 점
- 145-146 °C (lit.)
- 밀도
- 1,1 g/cm3
- 증기압
- 0.8 mm Hg ( 20 °C)
- FEMA
- 4250 | PIPERAZINE
- 굴절률
- 1.4460
- 인화점
- 65 °C
- 저장 조건
- Store below +30°C.
- 용해도
- H2O: 0.1 M at 20 °C, clear, colorless
- 산도 계수 (pKa)
- 9.83(at 23℃)
- 물리적 상태
- Crystalline Flakes
- 색상
- White to slightly yellow
- 냄새
- at 0.10 % in dipropylene glycol. ammoniacal
- 수소이온지수(pH)
- 11.0-12.5 (25℃, 0.1M in H2O)
- 폭발한계
- 14%
- ?? ??
- ammoniacal
- 수용성
- 150 g/L (20 ºC)
- 감도
- Air Sensitive & Hygroscopic
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.035
λ: 280 nm Amax: 0.010
- JECFA Number
- 1615
- Merck
- 14,7464
- BRN
- 102555
- 노출 한도
- ACGIH: TWA 0.03 ppm
- 안정성
- Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
- InChIKey
- GLUUGHFHXGJENI-UHFFFAOYSA-N
- LogP
- -1.24 at 20-25℃
- CAS 데이터베이스
- 110-85-0(CAS DataBase Reference)
- NIST
- Piperazine(110-85-0)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 34-42/43-52/53-62-52-63 | ||
안전지침서 | 22-26-36/37/39-45-61 | ||
유엔번호(UN No.) | UN 2579 8/PG 3 | ||
WGK 독일 | 1 | ||
RTECS 번호 | TK7800000 | ||
F 고인화성물질 | 3-8-23 | ||
위험 참고 사항 | Harmful/Corrosive | ||
TSCA | Yes | ||
HS 번호 | 2933 59 95 | ||
위험 등급 | 8 | ||
포장분류 | III | ||
유해 물질 데이터 | 110-85-0(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 2600 mg/kg LD50 dermal Rabbit 8300 mg/kg | ||
기존화학 물질 | KE-28758 |
피페라진 C화학적 특성, 용도, 생산
개요
Piperazine is contained in pyrazinobutazone, an equimolecular sah of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory, in nurses and in veterinarians.화학적 성질
Piperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.용도
Labelled Piperazine정의
ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.Indications
Piperazine (Vermizine) contains a heterocyclic ring that lacks a carboxyl group. It acts on the musculature of the helminths to cause reversible flaccid paralysis mediated by chloride-dependent hyperpolarization of the muscle membrane. This results in expulsion of the worm. Piperazine acts as an agonist at gated chloride channels on the parasite muscle.Piperazine has been used with success to treat A. lumbricoides and E. vermicularis infections, although mebendazole is now the agent of choice. Piperazine is administered orally and is readily absorbed from the intestinal tract. Most of the drug is excreted in the urine within 24 hours.
Piperazine is an appropriate alternative to mebendazole for the treatment of ascariasis, especially in the presence of intestinal or biliary obstruction. Cure rates of more than 80% are obtained following a 2-day regimen.
Side effects occasionally include gastrointestinal distress, urticaria, and dizziness. Neurological symptoms of ataxia, hypotonia, visual disturbances, and exacerbations of epilepsy can occur in patients with preexisting renal insufficiency. It should not be used in pregnant women because of the formation of a potentially carcinogenic and teratogenic nitrosamine metabolite. Concomitant use of piperazine and chlorpromazine or pyrantel should be avoided.
World Health Organization (WHO)
Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)일반 설명
Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.공기와 물의 반응
Flammable. Absorbs water and carbon dioxide from air. Soluble in water.반응 프로필
1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .건강위험
Piperazine is a corrosive substance. The solidand its concentrated aqueous solutions areirritants to the skin and eyes. The irritanteffect in rabbits’ eyes was severe.The toxic symptoms from ingestion ofpiperazine include nausea, vomiting, excitement,change in motor activity, somnolence,and muscle contraction. The toxicity of thiscompound is low, however. The oral LD50value in rats is 1900 mg/kg. The inhalationtoxicity is very low. The inhalation LC50value in mice is 5400 mg/m3/2 h.
화재위험
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.Pharmaceutical Applications
A synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.색상 색인 번호
Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.Pharmacokinetics
Activity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.Clinical Use
Hexahydropyrazine or diethylenediamine (Arthriticine,Dispermin) occurs as colorless, volatile crystals of the hexahydratethat are freely soluble in water. After the discoveryof the anthelmintic properties of a derivative diethylcarbamazine,the activity of piperazine itself was established.Piperazine is still used as an anthelmintic for the treatmentof pinworm (Enterobius [Oxyuris] vermicularis) and roundworm(Ascaris lumbricoides) infestations. It is available invarious salt forms, including the citrate (official in the USP)in syrup and tablet forms. Piperazine blocks the response of the ascaris muscleto acetylcholine, causing flaccid paralysis in the worm,which is dislodged from the intestinal wall and expelled inthe feces.부작용
Some people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.Safety Profile
Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.잠재적 노출
(Piperazine): Primary irritant (w/o allergic reaction),Carcinogenicity
No increase in lung adenomas was produced in mice administered 0.69–18.75mg of piperazine/ kg in drinking water for 20–25 weeks and sacrificed 10–13 weeks later. Mice fed the equivalent of 938 mg/kg in the diet for 28 weeks and sacrificed at 40 weeks failed to show any significant increase in the incidence of lung adenomas. An increase in lung adenomas was produced in this bioassay by administration of piperazine together with sodium nitrate, suggesting the formation of the active nitroso derivative. Sodium ascorbate inhibited tumor formation, in theory, by preventing piperazine nitrosation (304). Coadministration of 250 ppm piperazine and 500 ppm sodium nitrate in drinking water did not produce tumors in rats. None of these studies were conducted using currently accepted methods for evaluating carcinogenic potential but piperazine alone, in these assays, was noncarcinogenic.환경귀착
This molecule has a simple chemical structure and molecular weight of 86.14. It has a strong alkaline base soluble in water (1:18), glycerol, and glycols, but is only sparingly soluble in alcohol and insoluble in ether. Piperazine is not expected to hydrolyze in water. The photodegradation half-life is approximately 0.8 h. The piperazine molecule is easily denaturalized by diverse environmental factors and has a low potential for bioaccumulation or biomagnification. To improve its stability, it is usually formulated as different salts such as adipate, citrate, phosphate, hexahydrate, and sulfate. Most piperazine salts are white crystalline powders that are readily soluble in water.Exceptions are adipates, which dissolve to only a maximum concentration of 5% in water, and phosphate, which is insoluble.운송 방법
UN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.Purification Methods
Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]비 호환성
Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.피페라진 준비 용품 및 원자재
원자재
피페라진 디하이드로클로라이드
에탄올아민
암모니아수
PIPERAZINE HEXAHYDRATE
파라핀 왁스
Solid sodium hydroxide
에탄올아민 하이드로클로라이드
에틸렌 클로로히드린
준비 용품
Ziprasidone hydrochloride monohydrate
트리포린
3-PIPERAZIN-1-YL-PROPIONITRILE
2-PIPERAZIN-1-YLISONICOTINIC ACID
1-BOC-PIPERAZINE
1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE
1-(2-CHLOROBENZYL)PIPERAZINE
Terazosin
1-(3-METHYLPYRIDIN-2-YL)PIPERAZINE
Flunarizine dihydrochloride
아미노-3-하이드라지노-5-머캅토-1,2,40트리아졸, 4-아미노-5-하이드라지노-1,2,4-트리아졸-3-티올
1-(CYCLOHEXYLCARBONYL)PIPERAZINE 97
피페라진 시트르산
4-(3-CHLOROPROPYL)-1-PIPERAZINE ETHANOL
1-(2-CHLORO-6-FLUOROBENZYL)PIPERAZINE
1-(4-PYRIDYLMETHYL)PIPERAZINE
1-(3-Nitorpyridin-2-yl)piperazine
1-(3-CHLOROBENZYL)PIPERAZINE
1-Boc-piperazine acetate
4-Piperazinobenzonitrile
아목사핀
PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE
1-(3-METHOXYPROPYL)-PIPERAZINE
Cefbuperazone
N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE
Sarafloxacin
1,4-피페라진디카르복살데하이드
비스(아미노프로필)피페라진
2-PIPERAZIN-1-YL-ACETAMIDEHYDROCHLORIDE
1-Butylpiperazine
TRANS-1-CINNAMYLPIPERAZINE
VESNARINONE
clopenthixol
1-[2-(4-PYRIDYL)ETHYL]PIPERAZINE
1-(1-Methyl-4-piperidinyl)piperazine
1-[3-(DIMETHYLAMINO)PROPYL]PIPERAZINE
1-(3-PHENYLPROPYL)PIPERAZINE
BENZYL 1-PIPERAZINECARBOXYLATE
1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine
Piperaquinoline
피페라진 공급 업체
글로벌( 585)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ZHEJIANG ESTCHEM CO.,LTD | 15957180504 |
sales@zjestchem.com | China | 193 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | CHINA | 34572 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29811 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Jiangsu Qingquan Chemical Co., Ltd. | +86-571-86589381,86589382,86589383 |
sales1@qqpharm.com | CHINA | 154 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2990 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29922 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | CHINA | 2933 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28184 | 58 |
피페라진 관련 검색:
2-(1-피페라지닐)피리미딘 피페라진 N-메틸피페라진 1-(2-하이드록시에틸)피페라진
METHYL PIPERAZINE-1-CARBOXYLATE
Piperidine hydrochloride
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Levofloxacin Tetrafluoro Impurity 1
Levofloxacin N-oxide
Levofloxacin carboxylic acid
1-Piperazinecarbaldehyde
Oxygen-fluorine acid
PIPERAZINE HEXAHYDRATE
1-Boc-piperazine acetate
PIPERAZINE DIHYDROCHLORIDE
Piperidine, 2-[4-(hydrazinylmethyl)phenyl]-
Imatinib Impurity 72
Piperidine, 1-benzoyl-4-methylene-