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디 -Tert- 부틸 디 카보네이트

디 -Tert- 부틸 디 카보네이트 구조식 이미지

카스 번호:: 24424-99-5

한글명:: 디 -Tert- 부틸 디 카보네이트

동의어(한글):: 디-T-부틸디탄산염;디-T-뷰틸디탄산염;디-T-뷰틸디탄산염(DI-T-BUTYLDICARBONATE)

상품명:: Di-tert-butyl dicarbonate

동의어(영문):: BOC;(BOC)2O;DIBOC;BOC ANHYDRIDE;DI-T-BUTYL DICARBONATE;DBDC;DI-TERT-BUTYL PYROCARBONATE;tert-Butoxycarbonyl Anhydride;Di-tert-butyL;tert-butyldicarbonate

CBNumber:: CB4267614

분자식:: C10H18O5

포뮬러 무게:: 218.25

MOL 파일:: 24424-99-5.mol

속성

안전

MSDS

용도

공급 업체 932

디 -Tert- 부틸 디 카보네이트 속성

녹는점: 23 °C (lit.)

끓는 점: 56-57 °C/0.5 mmHg (lit.)

밀도: 0.95 g/mL at 25 °C (lit.)

증기압: 3.85Pa at 25℃

굴절률: n20/D 1.409(lit.)

인화점: 99 °F

저장 조건: 2-8°C

용해도: Chloroform (Sparingly), Methanol (Slightly)

물리적 상태: Low Melting Crystalline Solid

색상: White

Specific Gravity: 0.950

수용성: Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.

감도: Moisture Sensitive

BRN: 1911173

안정성: Acid Sensitive

InChIKey: DYHSDKLCOJIUFX-UHFFFAOYSA-N

LogP: 1.87 at 25℃

CAS 데이터베이스: 24424-99-5(CAS DataBase Reference)

EPA: Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	T+,T,F,Xi,F+
위험 카페고리 넘버	11-19-26-36/37/38-43-10-40
안전지침서	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
유엔번호(UN No.)	UN 2929 6.1/PG 1
WGK 독일	3
RTECS 번호	HT0230000
F 고인화성물질	4.4-10-21
자연 발화 온도	460 °C
위험 참고 사항	Flammable/Irritant/Very Toxic
TSCA	Yes
위험 등급	6.1
포장분류	I
HS 번호	29209010
독성	LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
기존화학 물질	KE-10019

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H226	인화성 액체 및 증기	인화성 액체	구분 3	경고
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318	눈에 심한 손상을 일으킴	심한 눈 손상 또는 자극성 물질	구분 1	위험	P280, P305+P351+P338, P310
H330	흡입하면 치명적임	급성 독성 물질 흡입	구분 1, 2	위험	P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P210	열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P233	용기를 단단히 밀폐하시오. 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 보관하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353	피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	3
4		1

디 -Tert- 부틸 디 카보네이트 MSDS

Di-tert-butyl dicarbonate

디 -Tert- 부틸 디 카보네이트 C화학적 특성, 용도, 생산

용도

Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.

제조 방법

The preparation of Di-tert-butyl dicarbonate is as follows:To a monoester sodium salt solution were added 2g of N, N-dimethylformamide, 1g of pyridine, 1g of triethylamine,Cooling to -5~0°C, 60g diphosgene was slowly added dropwise within 1.5h dropwise addition was complete, warmed to room temperature (25°C), incubated for 2h, the reaction was allowed to stand after filtration, washing organic solution. Dried with anhydrous magnesium sulfate, the solvent was distilled off at atmospheric pressure to give crude product 65~70g. After cooling and crystallization, 57-60g of di-tert-butyl dicarbonate were obtained in a yield of 60-63%.

정의

ChEBI: Di-tert-butyl dicarbonate is an acyclic carboxylic anhydride. It is functionally related to a dicarbonic acid.

화학 반응

The reaction of substituted anilines with Boc2O in the presence of a stoichiometric amount of 4-dimethylaminopyridine (DMAP) in an inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) at room temperature leads to aryl isocyanates in almost quantitative yields within 10 min.
Di-tert-butyl dicarbonate and 4-(dimethylamino)pyridine revisited. Their reactions with amines and alcohols

일반 설명

Di-tert-butyl dicarbonate (Boc₂O) is a reagent mainly used for the introduction of the Boc protecting group to amine functionalities. It is also used as a dehydrating agent in some organic reactions, particularly with carboxylic acids, certain hydroxyl groups, or with primary nitroalkanes.

위험도

An irritant that may cause serious eye injury; May cause skin sensitization; Highly toxic by inhalation

Purification Methods

Melt the ester by heating at ~35o, and distil it in a vacuum. If IR and NMR ( 1810m 1765 cm-1 , in CCl4 1.50 singlet) suggest very max impure, then wash with an equal volume of H2O containing citric acid to make the aqueous layer slightly acidic, collect the organic layer and dry it over anhydrous MgSO4 and distil it in a vacuum. [Pope et al. Org Synth 57 45 1977, Keller et al. Org Synth 63 160 1985, Grehn et al. Angew Chem 97 519 1985.] FLAMMABLE.

디 -Tert- 부틸 디 카보네이트 준비 용품 및 원자재

원자재

포타슘터셔리부톡사이드 노르말옥탄 이산화탄소 사염화탄소 1,8-디아자비사이클로[5.4.0]운덴센-7 테트라하이드로푸란

준비 용품

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-4-Boc-2-piperazinecarboxylic acid TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE 1-BOC-PIPERAZINE TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE TERT-BUTYL 3-(4-AMINO-2,6-DICHLOROPHENOXY)PROPYLCARBAMATE 1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE 스페르미딘 3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE tert-Butyl N-(2-bromoethyl)carbamate 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID TERT-BUTYL 4-FORMYL-2-METHOXYPHENYL CARB ONATE, 99 (S)-N-Boc-allylglycine N-BOC-piperidine-4-carboxylic acid TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE 4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-3-oxopiperazine 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID 1-(4-PYRIDYLMETHYL)PIPERAZINE 6-(BOC-AMINO)-HEXYL BROMIDE BOC-L-Isoleucine 1-Boc-piperazine acetate 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE 4-CHLORO-(N-BOC)ANILINE 97 BOC-L-Prolinol N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE N-Boc-D-proline N-Boc-N,N-bis(2-chloroethyl)amine 4-(BOC-AMINOMETHYL)PYRIDINE N-1-BOC-N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID T-BUTYL ESTER TERT-BUTYL 4-(METHOXYCARBONYL)PYRIDIN-2-YLCARBAMATE 4-BOCAMINO-NICOTINIC ACID (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 6-BOC-HYDRAZINONICOTINIC ACID TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID (R)-PIPERAZINE-2-CARBOXYLIC ACID (3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 1-Boc-4-cyanopiperidine

디 -Tert- 부틸 디 카보네이트 공급 업체

글로벌( 932)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Wuhan Aoliqisi New Material Technology Co., Ltd.	+8613545906766	sales@whaop.com	China	287	58
Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.	+86-86-02586819868 +8613913839793	sales@jinchemical.com	China	23	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17369	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8350	58
Shandong Zhishang New Material Co., Ltd.	+8617653113209	sales002@sdzschem.com	China	3051	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1257	58
XuZhou Magic Biotechnology Co., Ltd.	+undefined13921770081	SVP01@magicbiotech.cn	China	86	58
Shijiazhuang Suking Biotechnology Co .,Ltd.	+86-17318586295	sales1@sxbiology.com	China	291	58
GenChem & GenPharm (Changzhou) Co., Ltd.	+86-86020003 +86-18861157602	sales03@genchem.cn	China	79	58

디 -Tert- 부틸 디 카보네이트 관련 검색:

메틸 에틸 카보네이트 포스겐 브푸로페진 아세트산부틸 아크릴산메틸 시할로폽부틸 디페닐 카르보네이트 부틸 올레인산염 다이부틸푸탈레이트 디이소뷰틸 프탈산 숙신산 디메틸 디에틸 카보네이트 디에틸 피로탄산염 디메틸 카보네이트 디 -Tert- 부틸 디 카보네이트 tert-부틸알코올 디부틸 세바케이트 부틸글리콜