프로게스테론

프로게스테론 속성

프로게스테론 MSDS

4-Pregnene-3,20-dione

프로게스테론 C화학적 특성, 용도, 생산

개요

Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ^4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells. Progesterone activates the human progesterone receptor with an EC₅₀ value of 0.5 nM.

화학적 성질

White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.

출처

Colchicum luteum also yields this alkaloid.

정의

ChEBI: Progesterone is a C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. It has a role as a contraceptive drug, a progestin, a progesterone receptor agonist, a human metabolite and a mouse metabolite. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid hormone. It derives from a hydride of a pregnane.

일반 설명

Progesterone, pregn-4-en-3,20-dione, is so rapidly metabolized that it is not particularlyeffective orally, being only one twelfth as active as intramuscularly.An oral formulation of micronized progesterone(Prometrium) is available. Progesterone given intramuscularlycan be very irritating. A vaginal gel containing 4% or8% progesterone offers an alternative dosage form.Progesterone was originally obtained from animal ovariesbut is now prepared synthetically from plant sterol precursors.The discovery of 19-nortestosterones with progesteroneactivity made synthetically modified progestins of tremendoustherapeutic importance.
Progesterone (and all other steroid 4-ene-3-ones) is lightsensitive and should be protected from light.

공기와 물의 반응

Insoluble in water.

반응 프로필

Progesterone is sensitive to light .

위험도

A carcinogen (OSHA).

건강위험

ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.

화재위험

Flash point data for Progesterone are not available; however, Progesterone is probably combustible.

생물학적 활성

Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).

Safety Profile

NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Lirmted Evidence IMEMDT 21,491,79; Animal Sufficient Evidence IMEMDT 6,135,74. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. SAFETY PROFILE: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intravenous and intraperitoneal routes. Human teratogenic effects by ingestion and parenteral routes: developmental abnormalities of the urogenital system. Human male reproductive effects by intramuscular route: changes in spermatogenesis, the prostate, seminal vesicle, Cowper's gland and accessory glands, impotence, and breast development. Human female reproductive effects by ingestion, parenteral, and intravaginal routes: ferthty changes; menstrual cycle changes and disorders; uterus, cervix, and vagina changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Carcinogenicity

Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

The 
form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]

프로게스테론 준비 용품 및 원자재

원자재

준비 용품

프로게스테론 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5905	58
Hanhong Medicine Technology (Hubei) Co., Ltd.	+86-027-027-86832068 +8618707181983	parr@hanhong-api.com	China	194	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9385	58
APOLLO HEALTHCARE RESOURCES	+6596580999	sales@apollo-healthcare.com.sg	Singapore	380	58
Wuhan Dujiang Industrial Co., Ltd.	+86-027-87110040 +86-18120567669	wei@dujiangsy.com	China	728	58
Shenzhen Monkono Technology Co.,Ltd	+86-17063441314	sansbiotech@outlook.com	China	677	58
Pharmaceuticals Group Corp., Ltd.	+8613004379774	wu@jiaerke.com	China	33	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	161	58
Shanghai Nuo Rui Hua New Material Technology Co., Ltd	+8615631980363	skye@sfinechem.com	China	47	58
Henan Tengmao Chemical Technology Co. LTD	+8618236990536	salesvip4@hntmhg.com	China	471	58

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