L-트립토판
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L-트립토판 속성
- 녹는점
- 289-290 °C (dec.)(lit.)
- 알파
- -31.1 º (c=1, H20)
- 끓는 점
- 342.72°C (rough estimate)
- 밀도
- 1.34
- 굴절률
- -32 ° (C=1, H2O)
- 저장 조건
- 2-8°C
- 용해도
- 20% NH3: 0.1 g/mL at 20 °C, clear, colorless
- 물리적 상태
- powder
- 산도 계수 (pKa)
- 2.46(at 25℃)
- 색상
- White to yellow-white
- 수소이온지수(pH)
- 5.5-7.0 (10g/l, H2O, 20℃)
- 냄새
- wh. cryst. or cryst. odorless powd., sl. bitter taste
- optical activity
- [α]20/D 31.5±1°, c = 1% in H2O
- 수용성
- 11.4 g/L (25 ºC)
- Merck
- 14,9797
- BRN
- 86197
- 안정성
- Stable. Incompatible with strong acids, strong oxidizing agents.
- InChIKey
- QIVBCDIJIAJPQS-VIFPVBQESA-N
- LogP
- 0.704 (est)
- CAS 데이터베이스
- 73-22-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 33-40-62-41-37/38-36/37/38-22 | ||
안전지침서 | 24/25-36/37/39-36-26 | ||
WGK 독일 | 2 | ||
RTECS 번호 | YN6130000 | ||
F 고인화성물질 | 8 | ||
TSCA | Yes | ||
HS 번호 | 29339990 | ||
유해 물질 데이터 | 73-22-3(Hazardous Substances Data) | ||
독성 | LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000). | ||
기존화학 물질 | KE-01428 |
L-트립토판 C화학적 특성, 용도, 생산
화학적 성질
Appearance: white crystalline powder. Odorless, slightly bitter taste;Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition).
Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH).
It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein.
용도
L-tryptophan is an essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. It acts as a natural dietary supplement and used as an antidepressant, anxiolytic and sleep aid. It is used as a precursor to niacin, indole alkaloids and serotonin. It acts as an important intrinsic fluorescent probe, which finds to estimate the nature of microenvironment of the tryptophan.정의
ChEBI: The L-enantiomer of tryptophan.World Health Organization (WHO)
L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use.일반 설명
White powder with a flat taste. An essential amino acid; occurs in isomeric forms.공기와 물의 반응
Slightly soluble in water.반응 프로필
Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.건강위험
ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes.화재위험
Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible.Safety Profile
Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.Purification Methods
Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]L-트립토판 준비 용품 및 원자재
원자재
Neutral protease
Α-PROTEIN
클로로아세틸 무수물
판크레아틴
DL-트립토판
L-Amino acids
인돌
카세인
안트라닐산
N-Acetyl-L-tryptophan
D(+)-Tryptophan
L-(-)-세린
3-(3-Indolyl)-2-oxopropanoic acid
H-D-TRP-OET HCL
Nalpha-FMOC-L-Tryptophan
준비 용품
L-트립토판 공급 업체
글로벌( 1031)공급 업체
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