메틸렌 블루, 트리수화물
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메틸렌 블루, 트리수화물 속성
- 녹는점
- 190 °C (dec.)(lit.)
- 밀도
- 0.98 g/mL at 25 °C
- 인화점
- 14 °C
- 저장 조건
- no restrictions.
- 용해도
- Soluble in water, chloroform; sparingly soluble in ethanol
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 2.6, 11.2(at 25℃)
- 색상 색인 번호
- 52015
- 색상
- Green
- 수용성
- 4 g/100 mL
- 최대 파장(λmax)
- 668 nm, 609 nm
- Merck
- 13,6085
- 안정성
- Stable. Incompatible with bases, reducing agents, strong oxidizing agents.
- 생물학 분야의 응용
- Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials
- InChIKey
- YAFGUSOAMIMROI-UHFFFAOYSA-M
- CAS 데이터베이스
- 7220-79-3(CAS DataBase Reference)
- IARC
- 3 (Vol. 108) 2016
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38-11 | ||
| 안전지침서 | 26-36-24/25-16-7 | ||
| 유엔번호(UN No.) | UN 1170 3/PG 2 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | SP5740000 | ||
| TSCA | Yes | ||
| HS 번호 | 32129000 |
| 그림문자(GHS): |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Warning | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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메틸렌 블루, 트리수화물 C화학적 특성, 용도, 생산
화학적 성질
Methylene Blue trihydrate is a dark green crystalline powder that has a bronze-like luster. When dissolved in water or alcohol, it creates a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It can also inhibit guanylate cyclase and has been used to treat cyanide poisoning and lower levels of methemoglobin.용도
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.제조 방법
Methylene blue is synthesized commercially by oxidation of N,N-dimethyl-phenylenediamine with sodium dichromate (Na2Cr2O7) in the presence of sodium thiosulfate (Na2S2O3), followed by further oxidation in the presence of N,N-dimethylaniline (NTP, 2008). Methylene blue hydrochloride is isolated by addition of 30% hydrochloric acid and of a saturated common salt solution to the dye solution; after filtration, the product is washed with a 2% common salt solution. Instead of sodium dichromate, manganese dioxide, and catalytic amounts of copper sulfate can be used for the oxidation (Berneth, 2008).Methylene blue of high purity can be obtained by chloroform extraction of impurities from solutions of raw dye in borate buffer at pH 9.5–10, followed by acidification of the aqueous solution and isolation of the dye (Berneth, 2008).
IARC Monographs
일반 설명
Methylene blue trihydrate appears as odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5. (NTP, 1992)공기와 물의 반응
Hygroscopic. Water soluble. Gives a blue solution in water.반응 프로필
Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.화재위험
Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.메틸렌 블루, 트리수화물 준비 용품 및 원자재
원자재
준비 용품
메틸렌 블루, 트리수화물 공급 업체
글로벌( 427)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
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deasea125996@gmail.com | China | 2180 | 58 |
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info@dakenchem.com | China | 18729 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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fandachem@gmail.com | China | 9378 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29922 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | CHINA | 2933 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28184 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39919 | 58 |
| TopScience Biochemical | 00852-68527855 |
info@itopbiochem.com | China Hong Kong | 902 | 58 |