아목시실린
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아목시실린 속성
- 녹는점
- 140 °C
- 끓는 점
- 743.2±60.0 °C(Predicted)
- 밀도
- 1.54±0.1 g/cm3(Predicted)
- 증기압
- 0Pa at 25℃
- 저장 조건
- 2-8°C
- 용해도
- Do you have solubility information on this product that you would like to share
- 산도 계수 (pKa)
- pKa 2.4 (Uncertain)
- 물리적 상태
- solid
- 색상
- Light yellow
- 수용성
- 4g/L at 25℃
- Merck
- 13,582
- BRN
- 7507120
- BCS Class
- 1,3
- 안정성
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- LSQZJLSUYDQPKJ-UWFZAAFLSA-N
- LogP
- 0.87 at 25℃
- CAS 데이터베이스
- 26787-78-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
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위험 카페고리 넘버 | 42/43 | ||
안전지침서 | 22-36/37 | ||
WGK 독일 | 2 | ||
RTECS 번호 | XH8300000 | ||
HS 번호 | 29411000 | ||
유해 물질 데이터 | 26787-78-0(Hazardous Substances Data) | ||
기존화학 물질 | KE-01416 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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아목시실린 C화학적 특성, 용도, 생산
화학적 성질
solid용도
Antibacterial;Bacterial transpeptidase inhibitor정의
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.Indications
Amoxycillin, like ampicillin, has a broad spectrum of use. Indications for use are the same as with ampicillin. Synonyms of this drug are amoxican, amoxil, larotid, robamox, trimox, vimox, utimox, and others. Undoubtedly, analogs of ampicillin that are substituted at the amine fragment of phenylglycine (azolcillin, mezlocillin, piperacillin) should be included in this same group of compounds.Antimicrobial activity
The antibacterial spectrum is identical to that of ampicillin and there are few differences in antibacterial activity . Like ampicillin, amoxicillin is unstable to most β-lactamases. It has useful activity against Helicobacter pylori (<1% resistance), and is included in most combination regimens for the treatment of H. pylori infections.원료
There is complete cross-resistance with ampicillin. Its action against many β-lactamase-producing strains can be restored by co-administration with β-lactamase inhibitors.색상 색인 번호
Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.Pharmacokinetics
Oral absorption: 75–90%Cmax 500 mg oral: 5.5–7.6 mg/L after 1–2 h
500 mg intramuscular: c. 14 mg/L after 1–2 h
Plasma half-life: 1 h
Volume of distribution: 0.3 L/kg
Plasma protein binding: 17–20%
Absorption and distribution
Oral absorption produces over twice the peak concentration achieved by comparable doses of ampicillin, allowing less frequent dosing intervals. Absorption is unaffected by food. It is well-distributed in multiple body fluids, including pleural, peritoneal and middle ear fluid. It does not penetrate well into the CSF.
Metabolism and excretion
Some 10–25% is converted to the penicilloic acid. Between 50% and 70% of unchanged drug is recovered in the urine in the first 6 h after a dose of 250 mg. Plasma levels are elevated and prolonged by the administration of probenecid.
Clinical Use
Amoxicillin, 6-[D-(-)-α-amino-p- hydroxyphenylacetamido]penicillanic acid (Amoxil, Larotid, Polymox), a semisyntheticpenicillin introduced in 1974, is simply the p-hydroxyanalog of ampicillin, prepared by acylation of 6-APA with phydroxyphenylglycine.Its antibacterial spectrum is nearly identical with that ofampicillin, and like ampicillin, it is resistant to acid, susceptibleto alkaline and β-lactamase hydrolysis, andweakly protein bound. Early clinical reports indicated thatorally administered amoxicillin possesses significantadvantages over ampicillin, including more complete GIabsorption to give higher plasma and urine levels, lessdiarrhea, and little or no effect of food on absorption.50Thus, amoxicillin has largely replaced ampicillin for thetreatment of certain systemic and urinary tract infectionsfor which oral administration is desirable. Amoxicillin isreportedly less effective than ampicillin in the treatment ofbacillary dysentery, presumably because of its greater GIabsorption. Considerable evidence suggests that oral absorptionof α-aminobenzyl–substituted penicillins (e.g.,ampicillin and amoxicillin) and cephalosporins is, at leastin part, carrier mediated, thus explaining their generallysuperior oral activity.Amoxicillin is a fine, white to off-white, crystallinepowder that is sparingly soluble in water. It is available invarious oral dosage forms. Aqueous suspensions are stablefor 1 week at room temperature.부작용
Amoxicillin is generally well tolerated, side effects being those common to penicillins, but including non-allergic rashes in patients with glandular fever. As the drug is well absorbed, diarrhea is generally infrequent and rarely sufficiently severe to require withdrawal of treatment.아목시실린 준비 용품 및 원자재
원자재
Penicillin G
나트륨 글리신산염
프로필렌
펜옥심틸 페니실린
EC 3.5.1.11
수소
중탄산나트륨(중조)
클로로포름산에틸
6-아미노페니실란 산
Propanimidamide, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-, (Z)- (9CI)
L-(+)-p-하이드록시페닐글리신
오메프라졸
에틸헥사노일클로라이드
2-Chloro-1,3,2-dioxaphospholane
준비 용품
아목시실린 공급 업체
글로벌( 610)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei ZB Gamay Biological Technology Co.,Ltd | +86-031189171450 +86-15632359451 |
chem@zbvet.net | China | 216 | 58 |
Shenzhen Excellent Biomedical Technology Co.,Ltd. | +86-0755-26050679 +86-15915472436 |
sale@ex-biotech.cn | China | 1031 | 58 |
Wuhan Marco Pharmaceutical Technology Co., Ltd. | +86-18572802410 18572802410 |
sales@marcopht.com | China | 120 | 58 |
shandong perfect biotechnology co.ltd | +8618596095638 |
sales@sdperfect.com | China | 242 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
Guangzhou PI PI Biotech Inc | +86-020-81716320 +86-18371201331 |
Sales@pipitech.com | China | 3635 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 31969 | 60 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |