폴리프로필렌 글리콜 에틸렌 산화물 중합체
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폴리프로필렌 글리콜 에틸렌 산화물 중합체 속성
- 녹는점
- 57-61 °C
- 끓는 점
- >200 °C(lit.)
- 밀도
- 1.095 g/mL at 25 °C
- 증기 밀도
- >1 (vs air)
- 증기압
- <0.3 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.466
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- H2O: at <70 °Csoluble
- 물리적 상태
- solution
- 색상
- APHA: ≤120, 50/50 in CH3OH
- 수소이온지수(pH)
- 5.0-7.5 (100g/L in H2O)
- pH 범위
- 5.0 - 7.5
- 수용성
- Miscible with water.
- 최대 파장(λmax)
- λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2
- Merck
- 13,7644
- LogP
- -1.293 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T | ||
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위험 카페고리 넘버 | 21-23/24/25-25-36/37/38 | ||
안전지침서 | 23-24/25-45-36/37/39-26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TP6164333 | ||
TSCA | Yes | ||
HS 번호 | 39059100 | ||
유해 물질 데이터 | 9003-11-6(Hazardous Substances Data) | ||
독성 | LD50 oral in rabbit: 35gm/kg | ||
기존화학 물질 | KE-24574 |
그림문자(GHS): | |||||||||||||||
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유해·위험 문구: |
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예방조치문구: |
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폴리프로필렌 글리콜 에틸렌 산화물 중합체 C화학적 특성, 용도, 생산
화학적 성질
Polyethylene-polypropylene glycol generally occur as white, waxy, free-flowing prilled granules, or as cast solids. They are practically odorless and tasteless. At room temperature, poloxamer 124 occurs as a colorless liquid.용도
Polyethylene-polypropylene glycol is a liquid surfactant polymer.생산 방법
Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. Ethylene oxide is then added to form the block copolymer.일반 설명
Pluronic? L-81 is a lipoprotein secretion inhibitor.Pharmaceutical Applications
Polyethylene-polypropylene glycol is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;Polyethylene-polypropylene glycol is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.Safety
Polyethylene-polypropylene glycol is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.Polyethylene-polypropylene glycol is not metabolized in the body.Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.
In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.
No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.
(mouse, IV): 1 g/kg
(mouse, oral): 15 g/kg
(mouse, SC): 5.5 g/kg
(rat, IV): 7.5 g/kg
(rat, oral): 9.4 g/kg
저장
Polyethylene-polypropylene glycol is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth.The bulk material should be stored in a well-closed container in a cool, dry place.
비 호환성
Depending on the relative concentrations, poloxamer 188 is incompatible with phenols and parabens.Regulatory Status
Included in the FDA Inactive Ingredients Database (IV injections; inhalations, ophthalmic preparations; oral powders, solutions, suspensions, and syrups; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.폴리프로필렌 글리콜 에틸렌 산화물 중합체 준비 용품 및 원자재
원자재
준비 용품
Deinking agent for paper
epoxy resin liquid crystal
polyoxyalkylene phosphate
에탄올아민
폴리우레탄 중합체
polyesters containing quarternary ammonium groups
polyurethane polysiloxane copolymer
polyurethane photosensitive prepolymer
Water soluble polyurethane resin
finishing agent for polyester fiber
SC series polyurethane leather finishing agent
Polyether,bicomponent
Yemianbao
클로르플루아주론
Pesticide synergist agent
Polyurethane rigid foam
Polyurethane foam plastic
Amino resin paint
finishing agent for wool baylan W-G3
water soluble polyurethane for wool shrinkresist agent
acrylonitrile fiber oiling agent 101
아크릴산메틸
폴리프로필렌 글리콜 에틸렌 산화물 중합체 공급 업체
글로벌( 538)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3978 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8877 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21975 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
fandachem@gmail.com | China | 9378 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 31969 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29922 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | CHINA | 2933 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28184 | 58 |
Henan Xiangtong Chemical Co., Ltd. | 86-371-61312303 |
info@hnxtchem.com | CHINA | 292 | 58 |
폴리프로필렌 글리콜 에틸렌 산화물 중합체 관련 검색:
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