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1,1′-카보닐디이미다졸

1,1′-카보닐디이미다졸 구조식 이미지

카스 번호:: 530-62-1

한글명:: 1,1′-카보닐디이미다졸

동의어(한글):: 1,1′-카보닐디이미다졸;N,N'-카보닐디이미다졸

상품명:: 1,1'-Carbonyldiimidazole

동의어(영문):: CDI;CARBONYLDIIMIDAZOLE;1,1'-CARBONYLDIIMIDAZOLE (CDI);DI(1H-IMIDAZOL-1-YL)METHANONE;N,N-CARBONYLDIIMIDAZOLE;Diimidazolyl ketone;1,1-CARBONYL DIIMIDAZOLE;5% Pd-BaSO4;CARBODIIMIDAZOLE;Di-imidazol-1-yl-methanone

CBNumber:: CB0215374

분자식:: C7H6N4O

포뮬러 무게:: 162.15

MOL 파일:: 530-62-1.mol

속성

안전

MSDS

용도

공급 업체 1004

1,1′-카보닐디이미다졸 속성

녹는점: 117-122 °C(lit.)

끓는 점: 288.83°C (rough estimate)

밀도: 1.303 g/mL at 25 °C

증기압: 0.006-0.012Pa at 20-25℃

굴절률: n20/D1.434

저장 조건: 2-8°C

용해도: Soluble in dimethylformamide.

물리적 상태: Crystalline Powder

산도 계수 (pKa): 2.90±0.10(Predicted)

색상: White to light cream

pH 범위: 7.7 at 50 g/l

수소이온지수(pH): 7.7 (50g/l, H2O, 20℃)

수용성: Insoluble in water

감도: Moisture Sensitive

Merck: 14,1819

BRN: 6826

안정성: Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.

InChIKey: PFKFTWBEEFSNDU-UHFFFAOYSA-N

CAS 데이터베이스: 530-62-1(CAS DataBase Reference)

EPA: 1H-Imidazole, 1,1'-carbonylbis- (530-62-1)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	C,Xi,Xn
위험 카페고리 넘버	22-34-36/37/38-40-36/38
안전지침서	26-36/37/39-45-37/39-27-36/37
유엔번호(UN No.)	UN 3263 8/PG 2
WGK 독일	2
F 고인화성물질	10-21
위험 참고 사항	Harmful/Corrosive/Moisture Sensitive
TSCA	T
위험 등급	8
포장분류	III
HS 번호	29332990
독성	LD50 orally in Rabbit: 1071 mg/kg
기존화학 물질	KE-04758

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501
H314	피부에 심한 화상과 눈에 손상을 일으킴	피부부식성 또는 자극성물질	구분 1A, B, C	위험		P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501

예방조치문구:

P260	분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P303+P361+P353	피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	1
3		1

1,1′-카보닐디이미다졸 MSDS

1,1'-Carbonyldiimidazole

1,1′-카보닐디이미다졸 C화학적 특성, 용도, 생산

화학적 성질

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

용도

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

주요 응용

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

제조 방법

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

일반 설명

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

Purification Methods

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

1,1′-카보닐디이미다졸 준비 용품 및 원자재

원자재

이미다졸 1-(트리메틸실일)-1H-이미다졸 ; N-(트리에틸실일)아미다졸 포스겐 벤젠

준비 용품

2-(Boc-aminomethyl)-piperidine 3-oxo-3-phenyl-propanamide 5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97% 3-Cyanomethylthiophene 4-AMINOMETHYL-BENZAMIDE 2,8-DICHLOROPYRIMIDO[5,4-D]PYRIMIDINE Progabide 2-AMINO-5-BROMOBENZAMIDE 2-Ethylpiperazine 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE Pazufloxacin 5-BROMOTHIOPHENE-2-CARBONITRILE N-Heptafluorobutyrylimidazole 4-(Boc-Aminomethyl)piperidine 8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 2-chloro-5-cyanopyridine 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE 1-Boc-2-Methylpiperazine 3-(1H-INDOL-3-YL)-1-PROPANAMINE 1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE 5-BROMO-2-BENZOXAZOLINONE 97 isoglutamine 3-BROMOTHIOPHENE-2-CARBOXAMIDE 1-Boc-4-(aminomethyl)piperidine 2,3-나프탈렌디아민 4-N-BOC-Aminopiperidine 5-AMINO-3-PYRIDINECARBONITRILE 4-Cyanopiperidine 옥소티아졸리딘

1,1′-카보닐디이미다졸 공급 업체

글로벌( 1004)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Baynoe Chem (Suzhou) Co., Ltd.	+86-512 65869404 +86-18934593683	sales06@baynoe.com	China	292	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24788	58
Shandong Believe Chemical PTE.LTD	+86-18553607090 +8618553607090	1093908296@qq.com	China	1750	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20356	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930507417 +86-19930507417	violeta@crovellbio.com	China	14741	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1218	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29811	60
Henan DaKen Chemical CO.,LTD.	+86-371-66670886	info@dakenchem.com	China	18729	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21975	55

1,1′-카보닐디이미다졸 관련 검색:

모르폴린 염화마그네슘 보린산 코발트 카보닐 1,1′-카보닐디이미다졸 1-메틸이미다졸 이미다졸 Nucleoside N-(2-Hydroxyethyl)pyrrolidine Pentamethyldiethylenetriamine CIS-HEXAHYDROISOINDOLINE HYDROGEN CHLORIDE Benzamidine hydrochloride Chromium nicotinate Terbinafine DICAPRYLYL CARBONATE Ethylene thiourea Pyridoxamine dihydrochloride 2,2'-DIMETHYL-1,1' CARBONYLDIIMIDAZOLE