テトラゾール 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
解説
テトラゾール，(a)，(b)の互変異性体があり，溶液で両異性体を分離することはできないが，フェニル置換体では，両異性体を単独に得ることができる．無色の板状結晶．融点156 ℃．水，エタノール，アセトン，酢酸に可溶，エーテル，ベンゼンに難溶．いくぶんの芳香族性をもち，酸化に対して比較的安定である．N原子についたH原子はプロトンとしてとれやすく，水溶液は酸性を示し，また金属と置き換わる．金属置換体は爆発性がある．
森北出版「化学辞典（第2版）
用途
医薬品構造原料、エアーバッグ用火薬
製造
テトラゾール，N原子4個とC原子1個からなる複素五員環の名称．アジ化水素HN3と乾いたシアン化水素HCNを縮合させてつくられる．
化学的特性
white crystals or crystalline powder
使用
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
主な応用
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
製造方法
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
定義
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
一般的な説明
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
健康ハザード
Fire may produce irritating, corrosive and/or toxic gases.
火災危険
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
純化方法
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]
テトラゾール 上流と下流の製品情報
原材料
準備製品