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L-5-Hydroxytryptophan

L-5-Hydroxytryptophan structure

CAS No.: 4350-09-8

Chemical Name:: L-5-Hydroxytryptophan

Synonyms: 5-HTP;5-HYDROXY-L-TRYPTOPHAN;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP

CBNumber:: CB9110025

Molecular Formula:: C11H12N2O3

Molecular Weight:: 220.22

MDL Number:: MFCD00064341

MOL File:: 4350-09-8.mol

MSDS File:: SDS

Last updated:2023-05-25 18:01:22

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L-5-Hydroxytryptophan Properties

Melting point	270 °C (dec.) (lit.)
alpha	-32.5 º (c=1,H2O on dry basis)
Boiling point	361.16°C (rough estimate)
Density	0.902 g/mL at 25 °C (lit.)
refractive index	n20/D 1.4850(lit.)
Flash point	175 °F
storage temp.	2-8°C
solubility	H₂O: 10 mg/mL
form	solid
pka	2.22±0.10(Predicted)
color	white
optical activity	[α]22/D 30°, c = 1 in H2O
Water Solubility	Slightly soluble
Merck	14,4847
BRN	88200
LogP	-0.140 (est)
CAS DataBase Reference	4350-09-8(CAS DataBase Reference)
FDA UNII	C1LJO185Q9
NCI Drug Dictionary	oxitriptan
ATC code	N06AX01
EPA Substance Registry System	L-5-Hydroxytryptophan (4350-09-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P330+P331+P310

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-65-20/21/22-20/21

Safety Statements

36-26

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

YN7110000

3-10

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29339990

NFPA 704

	1
2		0

L-5-Hydroxytryptophan price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL80477	5-Hydroxy-L-tryptophan phyproof? Reference Substance	4350-09-8	50MG	$250	2023-06-20	Buy
Sigma-Aldrich	107751	5-Hydroxy-L-tryptophan 98% (calc. on dried substance)	4350-09-8	1g	$42.7	2023-06-20	Buy
Sigma-Aldrich	PHR2597	5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material	4350-09-8	100MG	$233	2022-05-15	Buy
Sigma-Aldrich	399698	5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor.	4350-09-8	25G	$466	2022-05-15	Buy
Sigma-Aldrich	1329913	5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard	4350-09-8	100mg	$400	2022-05-15	Buy

Product number	Packaging	Price	Buy
PHL80477	50MG	$250	Buy
107751	1g	$42.7	Buy
PHR2597	100MG	$233	Buy
399698	25G	$466	Buy
1329913	100mg	$400	Buy

L-5-Hydroxytryptophan Chemical Properties,Uses,Production

Chemical Properties

white to pale grey powder

Uses

A labelled metabolite of Tryptophan

Uses

5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan

Uses

5-Hydroxy-L-tryptophan has been used:

to inject experimental mice for serotonin detection
as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis

Definition

ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.

General Description

Colorless to pale pink crystals.

Air & Water Reactions

L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .

Reactivity Profile

L-5-Hydroxytryptophan reacts with bases. .

Fire Hazard

Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.

Biochem/physiol Actions

Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

Purification Methods

Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

L-5-Hydroxytryptophan synthesis

Synthesis of L-5-Hydroxytryptophan from 1H-Indole-3-propanamide, α-amino-5-hydroxy-, (αS)-

L-5-Hydroxytryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

Tryptamine

L-5-Hydroxytryptophan Suppliers

Global( 443)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Gihi Chemicals Co., Limited	+86-0571-86217390 +8618058761490	info@gihichem.com	China	998	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+undefined13970866816	info@zybiopharma.com	China	246	58
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD	15202951039	jason@sgonekbio.com	China	268	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29811	60
Henan DaKen Chemical CO.,LTD.	+86-371-66670886	info@dakenchem.com	China	18729	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21975	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	31969	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29922	58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD	+86-19933070948 +86-19930599843	claire@hbyingong.com	China	945	58
Jinan Jianfeng Chemical Co., Ltd	+8615562555968	info@pharmachemm.com	China	232	58

Supplier	Advantage
Gihi Chemicals Co., Limited	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	58
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD	58
Capot Chemical Co.,Ltd.	60
Henan DaKen Chemical CO.,LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD	58
Jinan Jianfeng Chemical Co., Ltd	58

View Lastest Price from L-5-Hydroxytryptophan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-11	L-5-Hydroxytryptophan 4350-09-8	US $1.00 / ASSAYS	1g	99.99%+	20T	Jinan Jianfeng Chemical Co., Ltd
2023-06-26	L-5-Hydroxytryptophan 4350-09-8	US $150.00 / ASSAYS	10g	>99%	500kg/month	HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
2023-02-24	5-Hydroxy-L-tryptophan 4350-09-8	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.

L-5-Hydroxytryptophan
4350-09-8
US $1.00 / ASSAYS
99.99%+
Jinan Jianfeng Chemical Co., Ltd

L-5-Hydroxytryptophan
4350-09-8
US $150.00 / ASSAYS
>99%
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD

5-Hydroxy-L-tryptophan
4350-09-8
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

L-5-Hydroxytryptophan Spectrum

L-5-Hydroxytryptophan(4350-09-8)MS L-5-Hydroxytryptophan(4350-09-8)¹HNMR L-5-Hydroxytryptophan(4350-09-8)IR1 L-5-Hydroxytryptophan(4350-09-8)IR2 L-5-Hydroxytryptophan(4350-09-8)Raman

4350-09-8(L-5-Hydroxytryptophan)Related Search:

Osthole O-2-propenyl-Tyrosine (S)-2-Amino-3-(4-ethylphenyl)propanoic acid H-L-Phe(4-CH2OtBu)-OH 3-(Trifluoromethoxy)-L-phenylalanine

(2S)-2-amino-3-[3,5-bis(trifluoromethyl)phenyl]propanoic acid (2S)-2-amino-3-(4-propoxyphenyl)propanoic acid 2-(Trifluoromethoxy)-L-phenylalanine 2-(1H-indol-3-yl)acetaldehyde 3-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione

2-(3-INDOLYLMETHYL)-L-TRYPTOPHAN L-Tryptophan, 2-sulfo- N-Acetyl-L-tryptophan 3-(phenylamino)alanine HARMANE-1,2,3,4-TETRAHYDRO-3-CARBOXYLIC ACID

Tryptophan Impurity 1（Tryptophan EP Impurity A） DL-METHIONINE SULFOXIDE L-2-hydroxyTryptophan hydrochloride

1of4

5-hydroxy-l-tryptopha pretonine L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID L-5-HYDROXYTRYPTOPHAN HYDRATE L-5-HYDROXYTRYPTOPHAN L-5-HTP 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID (-)-5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRP-OH 5-HYDROXY-TRP-OH 5-HTP C5-HYDROXY-L-TRYPTOPHAN H-5-HYDROXY-TRP-OH H-TRP(5-OH)-OH (S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid Levothym L-5-Hydroxytryptophan,99% L-5-Hydroxytryptopha (S)-5-Hydroxytryptophan 5-Hydroxytryptophan(5-HTP,Oxitriptan) (S)-2-AMino-3-(5-hydroxy-1H-indol-3-yl)-propionic acid, C5-Hydroxy-L-tryptophan, 5-HTP, Oxitriptan 5-Hydroxy-L-tryptophan-d 3 L-5-Hydroxytryptophan, 99% 1GR L-5-Hydroxytryptophan, 99% 5GR L-5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid 5-Hydroxy-L-tryphophane (S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 5-Hydroxy-L-tryptophan(5-HTP) 5-Hydroxy-L-tryptophan99% L-Trp(5-OH)-OH OXITRIPTAN 5-Hydroxy-L-tryptophan, Free Acid Griffonia seed L-Tryptophan, 5-hydroxy- l-2-amino-3-[3-(5-hydroxyindole)]propionic acid 5-HYDROXY-1-TRYTOPHAN 5-Hydroxyl-L-tryptophan. quietim 5-HYDROXY-L-TRYPTOPHAN 99,0 % min 5-Hydroxy-L-tryptophane H-L-Trp(5-OH)-OH 5-HTP Griffonia Seed L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP 5-HYDROXY-L-TRYPTOPHAN 99% 5-HTP HPLC L-2-Amino-3-(5-hydroxyindolyl)propionic acid L-5-HTP 5-HTP 5-Hydroxy-L-tryptophan, Dihydrate L-HTP Tryptophan Impurity 9（Tryptophan EP Impurity D） L-5-Hydroxytryptophan (Synonyms: L-5-HTP Ghana seed extract L-5-Hydroxytryptophan (L-5-HTP L-5-Hydroxytryptophan(Tryptophan EP Impurity D) HPLC>=98% 5-Hydroxy-L-tryptophan> (S)-2-Amino-3-(5-hydroxy-1H-indol-3