| Identification | Back Directory | [Name]
LIDOFLAZINE, 98.5% | [CAS]
3416-26-0 | [Synonyms]
R-7904
clinium
klinium
lidoflazin
corflazine
mcn-jr7904
ordiflazine
lidoflazina
lidoflazinum
LIDOFLAZINE, 98.5%
6’-xylidide,4-(4,4-bis(p-fluorophenyl)butyl)-1-piperazineaceto-2
4-(4,4-bis(p-fluorophenyl)butyl)-1-piperazineaceto-2’,6’-xylidide
1-(4,4-bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)piperaz
1-piperazineacetamide,4-(4,4-bis(4-fluorophenyl)butyl)-n-(2,6-dimethylphenyl
4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide | [EINECS(EC#)]
222-312-8 | [Molecular Formula]
C30H35F2N3O | [MDL Number]
MFCD00057353 | [MOL File]
3416-26-0.mol | [Molecular Weight]
491.622 |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO ALMOST WHITE POWDER | [Melting point ]
159-161° | [Boiling point ]
632.6±55.0 °C(Predicted) | [density ]
1.1322 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [pka]
14.62±0.70(Predicted) | [color ]
white | [CAS DataBase Reference]
3416-26-0 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO ALMOST WHITE POWDER | [Uses]
Coronary vasodilatator;Ca++ channel activator | [Originator]
Clinium,Janssen,W. Germany,1969 | [Definition]
ChEBI:2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane. | [Manufacturing Process]
A mixture of 6.6 parts 1-[4,4-di-(4-fluoro-phenyl)butyl]-piperazine, 4.33 parts
N-(2-chloro-acetyl)-2,6-dimethyl-aniline, 3.2 parts sodium carbonate, a few
crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and
refluxed for 70 hours. After cooling there are added 70 parts water. The
organic layer is separated, dried over potassium carbonate, filtered and
evaporated. The oily residue is dissolved in 80 parts diisopropylether and the
solution is filtered hot. After cooling the filtrate at 0°C. the formed solid is
filtered off and recystallired from 80 parts ether, yielding 1-[4,4-di-(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilino-carbonyl)-methyl]-piperazine; MP 159°C
to 161°C. | [Brand name]
Angex (Janssen);
Clinium (Ortho-McNeil). | [Therapeutic Function]
Coronary vasodilator | [storage]
Store at -20°C |
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