| Identification | Back Directory | [Name]
L-745,870 TRIHYDROCHLORIDE | [CAS]
158985-00-3 | [Synonyms]
3HCl
L 745870
L-745,870 TRIHYDROCHLORIDE
3-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine
1H-Pyrrolo[2,3-b]pyridine, 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-
3-(4-[4-CHLOROPHENYL]PIPERAZIN-1-YL)-METHYL-1H-PYRROLO[2,3-B]PYRIDINE TRIHYDROCHLORIDE | [Molecular Formula]
C18H19ClN4 | [MDL Number]
MFCD01074795 | [MOL File]
158985-00-3.mol | [Molecular Weight]
326.82 |
| Hazard Information | Back Directory | [Uses]
L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials. | [Definition]
ChEBI: 3-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1H-pyrrolo[2,3-b]pyridine is a member of piperazines. | [Biological Activity]
A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors. |
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